Erhaltungstherapie mit Methadontabletten - Eine Übersicht
Erhaltungstherapie mit Methadontabletten - Eine Übersicht
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Monoamine Oxidase (MAO) Inhibitors – Therapeutic doses of meperidine have precipitated severe reactions hinein patients concurrently receiving monoamine oxidase inhibitors or those Weltgesundheitsorganisation have received such agents within 14 days. Similar reactions thus far have not been reported with methadone.
When treating pain, methadone given on a fixed-dose schedule may have a narrow therapeutic Stichwortverzeichnis in certain patient populations, especially when combined with other drugs, and should be reserved for cases where the benefits of opioid analgesia with methadone outweigh the known potential risks of cardiac conduction abnormalities, respiratory depression, altered mental states and postural hypotension.
Benztropine and amitriptyline. Taking these drugs with methadone may cause urinary retention (not being able to fully empty your bladder), constipation, and slowed movement hinein your stomach and bowels. This can lead to a severe bowel obstruction.
Methadone-maintained patients beginning treatment with these antiretroviral drugs should Beryllium monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly.
Rein the selection of an initial dose of methadone hydrochloride tablets, attention should be given to the following:
If these side effects are mild, they may go away within a few days or a couple of weeks. If they’Bezeichnung für eine antwort im email-verkehr more severe or don’t go away, talk to your doctor or pharmacist.
Additional information on the potential risks of methadone may be derived from animal data. Methadone does not appear to be teratogenic hinein the rat or rabbit models. However, following large doses, methadone produced teratogenic effects hinein the guinea pig, hamster and maus. One published study hinein pregnant hamsters indicated that a single subcutaneous dose of methadone ranging from 31 to 185 Magnesium/kg (the 31 Magnesium/kg dose is approximately 2 times a human daily oral dose of 120 Magnesium/day on a Magnesium/m2 Lager) on day 8 of gestation resulted hinein a decrease hinein the number of fetuses über litter and an increase rein the percentage of fetuses exhibiting congenital malformations described as exencephaly, cranioschisis, and “various other lesions”.
Rifampin – In patients well-stabilized on methadone, concomitant administration of rifampin resulted rein a marked reduction in serum methadone levels and a concurrent appearance of withdrawal symptoms.
The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe.
Proper assessment Methadontabletten ohne Rezept online of the patient, proper prescribing practices, periodic Response-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs.
During pregnancy a woman's methadone dose may need to Beryllium increased, or their dosing interval decreased. Methadone should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
Some data also indicate that methadone acts as an antagonist at the Stickstoff-methyl-D-aspartate (NMDA) receptor. The contribution of NMDA receptor antagonism to methadone's efficacy is unknown. Other NMDA receptor antagonists have been shown to produce neurotoxic effects in animals.
Patients seeking to discontinue methadone maintenance treatment of opioid dependence should be apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment.
However, the risk is highest when you first Ausgangspunkt taking the drug and after a dosage increase. Your risk may also Beryllium higher if you’Bezeichnung für eine antwort im email-verkehr older or already have breathing or lung problems.